| 产品编号 | bsm-63463R |
| 英文名称 | Phospho-ABL1 (Tyr245) Recombinant Rabbit mAb |
| 中文名称 | |
| 别 名 | ABL; BCR-ABL; CHDSKM; JTK7; bcr/abl; c-ABL; c-ABL1; p150; v-abl; E430008G22Rik; ABL1_HUMAN; ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; 2.7.10.2; ABL1_MOUSE; ABL proto-oncogene 1, non-receptor tyrosine kinase; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kinase; c-abl oncogene 1, non-receptor tyrosine kinase; Tyrosine-protein kinase ABL1 |
| 抗体来源 | Rabbit |
| 克隆类型 | Recombinant |
| 克 隆 号 | 2H0 |
| 交叉反应 | Human |
| 产品应用 | WB=1:2000-10000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000,ELISA=1:5000-20000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 |
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr SWISS: P00519 Gene ID: 25 非受体酪氨酸激酶c-Abl广泛表达于各组织细胞中,c-Abl是非受体酪氨酸激酶Src家族的一个成员。在生理状态下,它可以定位于多个亚细胞结构(如细胞核、细胞质、线粒体等)中并呈现不同功能。经研究认为,细胞核内的c-Abl在细胞凋亡调控以及DNA损伤修复过程中起重要作用,而胞质中的c-Abl则与细胞黏附、细胞分化及氧化应激有关联，该蛋白主要用于细胞凋亡的研究. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
