| 产品编号 | bsm-63551R |
| 英文名称 | GRN | Granulin Recombinant Rabbit mAb |
| 中文名称 | |
| 别 名 | CLN11; FTD2; GEP; GP88; PCDGF; PEPI; PGRN; epithelin; GRN_HUMAN; GRN; Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda (GP88 | Glycoprotein 88); Granulin precursor; PC cell-derived growth factor (PCDGF); Proepithelin (PEPI); GRN_MOUSE; Epithelin/granulin precursor; progranulin; Granulins; Proepithelin; [Cleaved into: Acrogranin; Paragranulin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin B; Granulin-4; Granulin A; Granulin-5; Granulin C; Granulin-6; Granulin D; Granulin-7; Granulin E; ] |
| 抗体来源 | Rabbit |
| 克隆类型 | Recombinant |
| 克 隆 号 | 1D1 |
| 交叉反应 | Human,Mouse,Rat |
| 产品应用 | WB=1:2000-10000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000,ELISA=1:5000-20000,IP=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 |
disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.,PTM:Granulins are disulfide bridged.,similarity:Belongs to the granulin family.,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney., SWISS: P28799 Gene ID: 2896 1.PGRN目前主要用于老年痴呆疾病。是65岁以下人群中第二种最常见的 痴呆形式，该蛋白的多量产生，能够损坏记忆和个性，而且还可能影响运动。这一发现也许可帮助解决关于该疾病病因的困惑： 痴呆症(FTD)是常见的神经退化疾病，可见，除微管相关的tau蛋白导致痴呆症外，又一个新的与痴呆症有关蛋白又被科学家发现。 2.颗粒蛋白前体（PGRN）在调节生长发育、损伤修复和促进细胞增殖等方面发挥重要作用。PGRN能促进肿瘤细胞过度增殖、增强细胞向外周侵袭的能力以及促进肿瘤组织血管新生，提示它可能是肿瘤治疗的一个非常重 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
