| 产品编号 | bsm-63558R |
| 英文名称 | Cyclin D2 Recombinant Rabbit mAb |
| 中文名称 | |
| 别 名 | KIAK0002; MPPH3; 2600016F06Rik; Vin-1; Vin1; cD2; CCND2_HUMAN; CCND2; CCND2_MOUSE; Cyl-2; CCND2_RAT; Vin-1 proto-oncogene; cyclin D2; G1/S-specific cyclin D2; G1/S-specific cyclin-D2 |
| 抗体来源 | Rabbit |
| 克隆类型 | Recombinant |
| 克 隆 号 | 3C2 |
| 交叉反应 | Human |
| 产品应用 | WB=1:2000-10000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000,ELISA=1:5000-20000,IP=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencep SWISS: P30279 Gene ID: 894 Cyclin D2与周期素D1一样，为细胞周期中G1期进入S期的一个重要调控因子。细胞周期素是周期素依赖激酶的调节因子，不同的细胞周期素控制着细胞周期中不同的特定阶段。Cyclin D2通过激活CdK4或CdK6等，促进DNA合成，加速细胞增殖。主要用于B细胞淋巴瘤、乳腺癌、头颈部鳞癌、食道癌、肝癌和肺癌等恶性肿瘤的研究。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
