| 产品编号 | bsm-63575R |
| 英文名称 | Phospho-Catenin-β (Ser552) Recombinant Rabbit mAb |
| 中文名称 | |
| 别 名 | CTNNB; EVR7; MRD19; NEDSDV; armadillo; Bfc; Catnb; Mesc; CTNB1_HUMAN; CTNNB1; Beta-catenin; CTNB1_MOUSE; CTNB1_RAT; catenin beta 1; catenin (cadherin-associated protein), beta 1 (88kD); catenin (cadherin-associated protein), beta 1, 88kDa; catenin (cadherin-associated protein), beta 1; Catenin-β; b-catenin; Beta catenin; Cadherin associated protein; Catenin (cadherin associated protein), beta 1, 88 kDa; Catenin beta-1; CHBCAT; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289; OK/SW-cl.35 |
| 抗体来源 | Rabbit |
| 克隆类型 | Recombinant |
| 克 隆 号 | 8D8 |
| 交叉反应 | Human,Mouse,Rat |
| 产品应用 | WB=1:2000-10000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000,ELISA=1:5000-20000,IP=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016], SWISS: P35222 Gene ID: 1499 细胞粘附蛋白（Call Adhesion Protein） β连环素蛋白β-catenin是一种多功能的蛋白质，能链接E-\N-,钙粘附分子具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发生发展及浸润密切相关。 在正常个体中，β-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，β-catenin作为Wnt/β-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。 在恶性肿瘤中，β-catenin的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
