| 产品编号 | bsm-63714R |
| 英文名称 | HER4/ErbB4 Recombinant Rabbit mAb |
| 中文名称 | |
| 别 名 | ALS19; HER4; p180erbB4; c-erbB-4; ERBB4_HUMAN; ERBB4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; 2.7.10.1; ERBB4_MOUSE; Mer4; ERBB4_RAT; Tyro-2; erb-b2 receptor tyrosine kinase 4; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; human epidermal growth factor receptor 4; Receptor tyrosine-protein kinase erbB-4 |
| 抗体来源 | Rabbit |
| 克隆类型 | Recombinant |
| 克 隆 号 | 11C4 |
| 交叉反应 | Human,Mouse,Rat |
| 产品应用 | WB=1:2000-10000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000,ELISA=1:5000-20000,IP=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008], SWISS: Q15303 Gene ID: 2066 细胞膜受体（Membrane Receptors) c-erbB-4蛋白过去一直为乳腺癌基因研究的主要方向，研究乳腺癌组织学分级及术后生存期的关系。目前认为他与细胞增殖活性和激素受体有一定的关联，有学者将c-erbB-4蛋白研究用于神经内分泌蛋白为主。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
