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Rabbit Anti-SH3GL3/HRP Conjugated antibody (bs-11702R-HRP) ~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-11702R-HRP
英文名称 Anti-SH3GL3/HRP
中文名称 辣根过氧化物酶标记的胞浆蛋白SH3GL3抗体
别    名 Endophilin I-III; Endophilin-III; CNSA3; EEN 2B L3; EEN B2; EEN2BL3; EENB2; Endophilin 3; Endophilin A3; H.sapiens mRNA for protein containing SH3 domain, SH3GL3; HsT19371; SH3 domain containing GRB2 like protein 3; SH3 domain GRB2 like 3; SH3 domain protein 2C; SH3D2C; SH3P13; SH3G3_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
产品应用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SH3GL3 (121-220aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The endophilins comprise a family of three SH3 domain-containing proteins designated Endophilin I, II and III, or alternatively known as SH3P4, SH3P8 and SH3P13, respectively. These proteins associate with Amphiphysin, Synaptojanin and Dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse, as Endophilin I is ex- pressed only in the brain. Both Endophilin II and Endophilin III are detected in a variety of tissues. Endophilin I is also implicated in modulating G protein-coupled receptor signaling by functioning as an adapter protein and directing 1 adrenergic receptors to the endocytic machinery.

Function:
SH3GL3 is implicated in endocytosis and may recruit other proteins to membranes with high curvature. It is found in brain and testis tissue. There are four isoforms.

Subunit:
Interacts with ARC (By similarity). Interacts with DNM1, SGIP1 and SYNJ1. Interacts with the huntingtin exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of insoluble polyglutamine-containing aggregates in vivo. Interacts with DYDC1. Interacts with FASLG. Interacts with ATX2.

Subcellular Location:
Cytoplasm, early endosome membrane, peripheral membrane protein. Note: Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons.

Tissue Specificity:
Brain and testis.

Similarity:
Belongs to the endophilin family.
Contains 1 BAR domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 6457 Human

Entrez Gene: 81921 Rat

Omim: 603362 Human

SwissProt: Q99963 Human

SwissProt: O35180 Rat

Unigene: 270055 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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