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Rabbit Anti-CD15/AF555 Conjugated antibody (bs-1702R-AF555) ~~~促销,代码KX240301~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1702R-AF555
英文名称 Anti-CD15/AF555
中文名称 AF555标记的阶段特异性胚胎表面抗原-1抗体
别    名 Fut4; SSEA-1; 3-FAL; Alpha (1,3) fucosyltransferase; Alpha 13 fucosyltransferase FucT; EC 2.4.1.; ELAM 1 ligand fucosyltransferase; ELAM ligand fucosyltransferase; ELAM1 ligand fucosyltransferase; ELFT; FCT3A; Fuc TIV; Fucosyltransferase 4 alpha 1 3 fucosyltransferase myeloid specific; Fucosyltransferase 4; FucT IV; FUCTIV; FUT4; Galactoside 3 L fucosyltransferase; Lewis X; LeX; SSEA 1; SSEA1; Stage specific embryonic antigen 1; FUC-TIV.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD15
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq].

Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Subcellular Location:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Tissue Specificity:
Highest expression in stomach and colon. It is also expressed in the lung, testis, uterus, small intestine and to a lesser extent in spleen, and ovary. Present in trace amounts in brain, thymus, heart, smooth muscle, kidney and bone marrow. Not found in liver, salivary gland and pancreas.

Similarity:
Belongs to the glycosyltransferase 10 family.

Database links:

Entrez Gene: 10690 Human

Entrez Gene: 2526 Human

Entrez Gene: 2527 Human

Entrez Gene: 2528 Human

Entrez Gene: 2529 Human

Omim: 104230 Human

SwissProt: P22083 Human

SwissProt: P51993 Human

SwissProt: Q11128 Human

SwissProt: Q11130 Human

SwissProt: Q9Y231 Human

Unigene: 390420 Human

Unigene: 457 Human

Unigene: 49117 Human

Unigene: 572064 Human

Unigene: 623098 Human

Unigene: 631843 Human

Unigene: 631846 Human

Unigene: 705615 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD15(SSEA-1)是胚胎干细胞表达胚胎阶段特异性抗原的主要SSEA-1蛋白,还包括、SSEA-3、TRA-1-81、TRA-1-60等。CD15主要存在于粒细胞(包括中性粒细胞和嗜酸性粒细胞)以及部分单核细胞上。它在介导细胞吞噬细菌和趋化性方面起重要作用。CD15常表达于霍奇金氏病中R-S细胞,尤其是经典型霍奇金淋巴瘤中。结节硬化型霍奇金淋巴瘤多为CD15阳性。CD15抗体是鉴定霍奇金氏病的一个有效工具。
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