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Rabbit Anti-SLC39A11/Cy5.5 Conjugated antibody (bs-9635R-Cy5.5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-9635R-Cy5.5
英文名称 Rabbit Anti-SLC39A11/Cy5.5 Conjugated antibody
中文名称 Cy5.5标记的溶质载体家族39成员11抗体
别    名 C17orf26; S39AB_HUMAN; SLC39A11; Solute carrier family 39 (metal ion transporter) member 11; Solute carrier family 39 member 11; Zinc transporter ZIP11; ZIP-11; ZIP11; Zrt and Irt like protein 11; Zrt- and Irt-like protein 11.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  信号转导  通道蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC39A11
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Zinc is an essential cofactor that is involved in cell growth and development, as well as in protein, nucleic acid and lipid metabolism. The transport of zinc across the cell membrane is crucial for correct enzyme and overall cell function. SLC39A11 (solute carrier family 39 (metal ion transporter), member 11), also known as ZIP11 (Zrt- and Irt-like protein 11), is a 342 amino acid multi-pass membrane protein belonging to the ZIP transporter family. Expressed as multiple alternatively spliced isoforms, SLC39A11 acts as a zinc-influx transporter and is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes, some of which are involved in tumor suppression and in the pathogenesis of Li-Fraumeni syndrome, early onset breast cancer and a predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Function:
May act as a zinc-influx transporter (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).

Similarity:
Belongs to the ZIP transporter (TC 2.A.5) family.

Database links:

Entrez Gene: 201266 Human

Entrez Gene: 69806 Mouse

Entrez Gene: 287796 Rat

SwissProt: Q8N1S5 Human

SwissProt: Q8BWY7 Mouse

SwissProt: Q6P6S2 Rat

Unigene: 221127 Human

Unigene: 341021 Mouse

Unigene: 205133 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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