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Rabbit Anti-CGRP/Cy5 Conjugated antibody (bs-0791R-Cy5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0791R-Cy5
英文名称 Rabbit Anti-CGRP/Cy5 Conjugated antibody
中文名称 Cy5标记的降钙素基因相关肽2抗体
别    名 CGRP-I + CGRP-II; CGRP-1/2; Procalcitonin; Beta type CGRP; CALC2; CALCB; Calcitonin 1; Calcitonin 2; Calcitonin gene related peptide; Calcitonin gene related peptide II; Calcitonin related polypeptide beta; CGRP; CGRP II; CGRP2; CT; Calcitonin/calcitonin related polypeptide alpha; Katacalcin; MGC126648; CALCA_HUMAN; CALCB_HUMAN; Calcitonin gene-related peptide 2; Beta-type CGRP; Beta-CGRP; Calcitonin gene-related peptide II; CGRP-II; CGRP-I.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  生长因子和激素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat,  (predicted: Mouse, Chicken, Pig, Cow, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 3.8kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CGRP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Subcellular Location:
Secreted.

Similarity:
Belongs to the calcitonin family.

Database links:

Entrez Gene: 796 Human

Entrez Gene: 797 Human

Entrez Gene: 116903 Mouse

Entrez Gene: 12310 Mouse

Entrez Gene: 171519 Rat

Entrez Gene: 24241 Rat

Omim: 114130 Human

Omim: 114160 Human

SwissProt: P01258 Human

SwissProt: P06881 Human

SwissProt: P10092 Human

SwissProt: P70160 Mouse

SwissProt: Q99JA0 Mouse

SwissProt: P01256 Rat

SwissProt: P01257 Rat

Unigene: 37058 Human

Unigene: 534305 Human

Unigene: 273838 Mouse

Unigene: 4361 Mouse

Unigene: 88080 Rat

Unigene: 90085 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


CGRP活性多肽,有37个氨基酸组成,具有多种生理功能,其药理作用已受到广泛重视.
CGRP (又称CGRP-1/2或CGRPa/β)广泛分布于神经系统的一种神经肽,在外周及脊髓参与伤害性信息的传递及痛敏化的形成,并与P物质、兴奋性氨基酸、辣椒素1型受体、趋化因子、激活素、大麻素受体、阿片受体、神经生长因子、血管活性肠肽、5-羟色胺、糖皮质激素等生物活性物质或受体在痛觉调制过程中存在相互影响。
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