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Rabbit Anti-HMGB1/FITC Conjugated antibody (bs-0664R-FITC) ~~~促销,代码KX240301~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0664R-FITC
英文名称 Anti-HMGB1/FITC
中文名称 FITC标记的高迁移率族蛋白B1抗体
别    名 Amphoterin; High mobility group 1; High Mobility Group Box 1; High mobility group protein 1; High mobility group protein B1; HMG3; HMGB 1;HMGB-1; Hmgb1 protein; Nonhistone chromosomal protein HMG1; SBP 1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; HMGB1_HUMAN.  
Journal
PMID
IF
Application
[IF=14.903] Tao He. et al. A tactical nanomissile mobilizing antitumor immunity enables neoadjuvant chemo-immunotherapy to minimize postsurgical tumor metastasis and recurrence. ACTA PHARM SIN B. 2022 Sep;:  FC ;  Mouse.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  转录调节因子  结合蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, Cow, )
产品应用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HMGB1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models

Function:
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

Subunit:
Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.

Subcellular Location:
Nucleus. Chromosome.

Similarity:
Belongs to the HMGB family.
Contains 2 HMG box DNA-binding domains.

Database links:

Entrez Gene: 282691 Cow

Entrez Gene: 3146 Human

Entrez Gene: 100862258 Mouse

Entrez Gene: 15289 Mouse

Entrez Gene: 25459 Rat

Omim: 163905 Human

SwissProt: P10103 Cow

SwissProt: P09429 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

近来的研究表明称之为高迁移率族蛋白B-1(HMG-B1)的核内结构蛋白在核外表达时是一种有效的早期炎症介质。
高迁移性B1组蛋白(HMGB1): 是一种核结合蛋白,在DNA重组、修复、复制和基因转录中起作用。HMGB1也是巨噬细胞分泌的一种介质。
此外,高迁移性B1组蛋白亦被受刺激的巨噬细胞或单核细胞主动分泌。在这一主动分泌过程中,HMGB1首先经乙酰化并由核内转移至溶酶体内,继而在ATP和溶血磷脂胆碱两种分泌信号指导下转移至细胞外。由坏死细胞被动释放的HMGB1和炎症细胞主动分泌的HMGB1存在分子上的差异。胞外的HMGB1可作为细胞因子参与信号传导,因为它既可识别Toll 样受体(TLR)家族的一些成员,又能与识别晚期糖基化终末产物受体(RAGE)相作用。
HMGB1能启动炎症反应,包括产生多种细胞因子、对某些干细胞产生趋化作用、诱导血管粘附分子、削弱肠上皮细胞的功能等。
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