| 产品编号 | bs-0815R-AF350 |
| 英文名称 | Anti-Megsin/AF350 |
| 中文名称 | AF350标记的丝氨酸蛋白酶抑制剂B7抗体 |
| 别 名 | SER-PINB7; MEGSIN; Mesangium predominant gene megsin; MGC120014; MGC120015; Serpin B7; Serpin peptidase inhibitor clade B (ovalbumin) member 7; TP55; SPB7_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat, (predicted: Human, Mouse, ) |
| 产品应用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Megsin (295-330aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 |
background: Serpin B7 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in a search for agents responsible for thrombopoiesis, and maturation of megakaryocytes. SerpinB7 was identified as a protein that increased acetylcholine esterase stimulation from bone barrow progenitor cells, and injection of SerpinB7 in mice induced a 40% increase in platelets compared to controls. Shortly thereafter, in a search for kidney specific genes, SerpinB7 was described as a protein specific to mesangial cells, and was named megsin to indicate the tissue specificity of the protein. Function: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in mesangial cells. Similarity: Belongs to the serpin family. Ov-serpin subfamily. Database links: Entrez Gene: 8710 Human Omim: 603357 Human SwissProt: O75635 Human Unigene: 138202 Human Unigene: 742388 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. megsin是新近发现的蛋白质,属于丝氨酸蛋白酶抑制剂（Serpin）超家族，特异表达于肾小球系膜细胞,其表达异常在肾脏疾病进展中具有重要作用,megsin蛋白适量的表达，对维持人体正常的生理病理过程如凝血、纤维溶解、间质代谢、发育、血压、肿瘤和炎症等是很重要的。在系膜细胞增生和系膜基质增多明显的IgA肾病肾小球中，megsin的表达显著上调。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
