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Rabbit Anti-Calreticulin/AF647 Conjugated antibody (bs-5913R-AF647) ~~~促销,代码KX240301~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-5913R-AF647
英文名称 Anti-Calreticulin/AF647
中文名称 AF647标记的钙网蛋白抗体
别    名 Autoantigen RO; CALR; CALR protein; CALR_HUMAN; Calregulin; Calreticulin; cC1qR; CRP55; CRTC; Endoplasmic reticulum resident protein 60; ERp60; grp60; HACBP; RO; Sicca syndrome antigen A; SSA.  
Journal
PMID
IF
Application
[IF=13.751] Ruikun Wang. et al. CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model. J Immunother Cancer. 2022 Jan;10(1):e003809  FC ;  Human.  
[IF=5.058] Axel Berg-Larsen. et al. Tumor growth inhibition and immune system activation following treatment with thorium-227 conjugates and PD-1 check-point inhibition in the MC-38 murine model.. FRONT MED-LAUSANNE. 2022 Nov;9:1033303-1033303  FCM ;  Mouse.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Calreticulin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.

Subunit:
Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with GABARAP.

Subcellular Location:
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface.

Similarity:
Belongs to the calreticulin family.

Database links:

Entrez Gene: 41166 Fruit fly (Drosophila melanogaster)

Entrez Gene: 811 Human

Entrez Gene: 12317 Mouse

Entrez Gene: 100009050 Rabbit

Entrez Gene: 64202 Rat

Omim: 109091 Human

SwissProt: P29413 Fruit fly (Drosophila melanogaster)

SwissProt: P27797 Human

SwissProt: P14211 Mouse

SwissProt: P15253 Rabbit

SwissProt: P18418 Rat

Unigene: 2457 Fruit fly (Drosophila melanogaster)

Unigene: 515162 Human

Unigene: 1971 Mouse

Unigene: 467043 Mouse

Unigene: 974 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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