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Rabbit Anti-CELSR2/FITC Conjugated antibody (bs-11818R-FITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-11818R-FITC
英文名称 Anti-CELSR2/FITC
中文名称 FITC标记的表皮生长因子样蛋白2抗体
别    名 Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; CDHF10; CELR2_HUMAN; Celsr2; EGF like domain multiple 2; EGF-like protein 2; EGFL2; epidermal growth factor like 2; Epidermal growth factor-like protein 2; Flamingo homolog 3; Flamingo1; KIAA0279; MEGF3; Multiple EGF-like domains protein 3; Multiple epidermal growth factor-like domains protein 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  信号转导  通道蛋白  细胞膜受体  G蛋白偶联受体  细胞骨架  细胞外基质  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 314kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CELSR2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons.

Function:
Receptor that may have an important role in cell/cell signaling during nervous system formation.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Highest expression in brain and testis.

Post-translational modifications:
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 9 cadherin domains.
Contains 7 EGF-like domains.
Contains 1 GPS domain.
Contains 1 laminin EGF-like domain.
Contains 2 laminin G-like domains.

Database links:

Entrez Gene: 100061311 Horse

Entrez Gene: 1952 Human

Entrez Gene: 53883 Mouse

Entrez Gene: 83465 Rat

Omim: 604265 Human

SwissProt: Q9HCU4 Human

SwissProt: Q9R0M0 Mouse

SwissProt: Q9QYP2 Rat

Unigene: 57652 Human

Unigene: 39728 Mouse

Unigene: 222746 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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