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Rabbit Anti-Myotrophin/AF594 Conjugated antibody (bs-11891R-AF594)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-11891R-AF594
英文名称 Anti-Myotrophin/AF594
中文名称 AF594标记的颗粒细胞分化蛋白抗体
别    名 FLJ31098; FLJ99857; GCDP; Granule cell differentiation protein; MTPN; MTPN_HUMAN; Myotrophin; Protein V 1; Protein V-1; V 1; MTPN_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  神经生物学  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from humam Myotrophin/GCDP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

Function:
Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy.

Subunit:
Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.

Subcellular Location:
Cytoplasm (Probable). Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity).

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the myotrophin family.
Contains 3 ANK repeats.

Database links:

Entrez Gene: 136319 Human

Entrez Gene: 14489 Mouse

Entrez Gene: 79215 Rat

Entrez Gene: 403487 Dog

Omim: 606484 Human

SwissProt: Q863Z4 Dog

SwissProt: P58546 Human

SwissProt: P62774 Mouse

SwissProt: P62775 Rat

SwissProt: Q7T2B9 Zebrafish

Unigene: 602015 Human

Unigene: 182746 Mouse

Unigene: 3239 Rat

Unigene: 75187 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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