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Rabbit Anti-SOHLH2/HRP Conjugated antibody (bs-12279R-HRP)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-12279R-HRP
英文名称1 Rabbit Anti-SOHLH2/HRP Conjugated antibody
中文名称 辣根过氧化物酶标记的精子卵子结合生成碱性螺旋蛋白2抗体
别    名 FLJ20449; FLJ57222; Solh2; Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2; TEB1; SOLH2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  干细胞  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, )
产品应用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human SOHLH2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SOHLH2 is a 425 amino acid nuclear protein that contains one basic helix-loop-helix (bHLH) domain through which it may function as a transcription factor during oogenesis and spermatogenesis. SOHLH2 exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 13q13.3. Chromosome 13 houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

Function:
Sohlh2, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2, is a basic loop helix transcription factor. Sohlh2 is normally expressed in pre-meiotic germ cells and testis and involved in spermatogenesis and oogenesis. Male Sohlh2 deficient mice are infertile due to a block in spermatogenesis.

Subcellular Location:
Nuclear

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

Database links:
UniProtKB/Swiss-Prot: Q9NX45.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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