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Rabbit Anti-GLUT6/GLUT9/RBITC Conjugated antibody (bs-13388R-RBITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-13388R-RBITC
英文名称 Anti-GLUT6/GLUT9/RBITC
中文名称 罗丹明(RBITC)标记的葡萄糖转运蛋白6抗体
别    名 Glucose Transporter GLUT6; A330096C23; F630103L12Rik; Glucose transporter type 6; Glucose transporter type 9; GLUT-6; GLUT-9; Glut6; Glut9; GTR6_HUMAN; HSA011372; RP23-449M10.2; SLC2A6; Solute carrier family 2, facilitated glucose transporter member 6.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  信号转导  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,  (predicted: Human, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GLUT6/Glucose Transporter GLUT6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The oxidation of glucose functions as the dominant source of metabolic energy for mammals. The plasma membrane is impermeable to glucose, so the cellular uptake of this important nutrient is achieved by facultative hexose transproters (Gluts). Gluts are integral membrane proteins that transport glucose and related hexoses. Glucose binds to a Glut on one side of the membrane which provokes a conformational change causing it to release glucose to the other side. Members of the Glut family may enhance the metabolic activity of tumor cells. Glut6 is part of the third out of three classes of Gluts. Glut6 is mainly expressed in the brain, spleen and peripheral leukocytes. It appears to be regulated by subcellular redistribution, because it is targeted to intracellular compartments by di-leucine motifs, recycling itself in a Dynamin-dependent manner.

Function:
Facilitative glucose transporter; binds cytochalasin B with low affinity.

Subcellular Location:
Cell membrane. The dileucine internalization motif is critical for intracellular sequestration.

Tissue Specificity:
Highly expressed in brain, spleen and peripheral blood leukocytes.

Similarity:
Belongs to the major facilitator superfamily.
Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Database links:

Entrez Gene: 11182 Human

Omim: 606813 Human

SwissProt: Q9UGQ3 Human

Unigene: 244378 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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