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Rabbit Anti-Gcn1l1/Gold Conjugated antibody (bs-13315R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-13315R-Gold
英文名称 Rabbit Anti-Gcn1l1/Gold Conjugated antibody
中文名称 胶体金标记的广泛控制氨基酸合成1样蛋白1抗体
别    名 GCN1; GCN1 (general control of amino acid synthesis yeast homolog) like; GCN1 (general control of amino acid synthesis 1 yeast) like 1; GCN1 general control of amino acid synthesis 1 like 1; GCN1 general control of amino acid synthesis 1 like 1 (yeast); GCN1 like protein 1; GCN1L; HsGCN1; GCN1L_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 细胞生物  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 293kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gcn1l1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
GCN1L1 is a 2,671 amino acid protein that is ubiquitously expressed and belongs to the GCN1 family. Functioning as a translation activator, GCN1L1 interacts with IMPACT to regulproteinate GCN2 kinase activity. GCN1L1 contains 24 HEAT repeats and is encoded by a gene that maps to human chromosome 12q24.23. Chromosome 12 encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

Function:
Gcn1l1 acts as a translation activator which mediates translational control and performs an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity.

Subunit:
Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4) (By similarity).

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Belongs to the GCN1 family.
Contains 24 HEAT repeats.

Database links:
UniProtKB/Swiss-Prot: Q92616.6

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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