| 产品编号 | bs-10428R-PE |
| 英文名称 | Anti-C2a/PE |
| 中文名称 | PE标记的补体C2a链多肽抗体 |
| 别 名 | Complement C2a fragment; C2; C2 protein; C3/C5 convertase; CO 2; CO2; complement C2; Complement component 2; complement component C2; DKFZp779M0311; OTTHUMP00000062690; CO2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 免疫学 糖蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human, ) |
| 产品应用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C2a |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 |
background: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]. Function: Component C2 which is part of the classical pathway ofthe complement system is cleaved by activated factor C1 into twofragments: C2b and C2a. C2a, a serine protease, then combines withcomplement factor 4b to generate the C3 or C5 convertase. Subunit: C2a interacts with Schistosoma haematobium TOR (viaN-terminal extracellular domain). This results in inhibition of theclassical and lectin pathway of complement activation, probably dueto interference with binding of C2a to C4b such that C3 convertasecannot be formed. This infers resistance to complement-mediatedcell lysis, allowing parasite survival and infection. Subcellular Location: Secreted. DISEASE: Defects in C2 are the cause of complement component 2deficiency (C2D) [MIM:217000]. A deficiency of the complementclassical pathway associated with the development of autoimmunedisorders, mainly systemic lupus erythematosus. Skin and jointmanifestations are common and renal disease is relatively rare.Patients with complement component 2 deficiency are also reportedto have recurrent or invasive infections. Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 3 Sushi (CCP/SCR) domains. Contains 1 VWFA domain. Database links: Entrez Gene: 717 Human Omim: 217000 Human SwissProt: P06681 Human Unigene: 408903 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
