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Rabbit Anti-GPR183/Biotin Conjugated antibody (bs-14497R-Bio)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-14497R-Bio
英文名称 Anti-GPR183/Biotin
中文名称 生物素标记的G蛋白偶联受体183抗体
别    名 ebi 2; EBI2; EBV induced G protein coupled receptor 2; EBV-induced G-protein coupled receptor 2; ebv-induced gene 2; Epstein-Barr virus-induced gene 2; Epstein Barr virus induced gene 2; epstein-barr virus induced gene 2; Epstein-Barr virus-induced G-protein coupled receptor 2; G protein-coupled receptor 183; G-protein coupled receptor 183; GP183_HUMAN; gpr183; Lymphocyte specific G protein coupled receptor.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  细菌及病毒  G蛋白偶联受体  G蛋白信号  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EBV Induced Gene 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
Epstein-Barr virus-induced gene 2 is a 357 amino acid multi pass membrane protein. It is expressed in B-lymphocytes and lymphoid tissues and may function in the modulation of the immune system. Out of the nine genes that are induced by the Epstein-Barr virus, Ebi2 exhibits the highest levels of up-regulation. Ebi2 is a G-protein coupled receptor that signals through the G-protein G錳. Ebi2 contains seven hydrophobic transmembrane regions and a putative N-linked glycosylation site at its extracellular N-terminus. Ebi2 is believed to be involved in regulating the effects of the Epstein-Barr virus on B-lymphocytes. In addition, Ebi2 may play a role mediating normal lymphocyte functions.

Function:
Orphan receptor that plays a central role during humoral immunity. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 1880 Human

Entrez Gene: 769212 Chicken

Entrez Gene: 540287 Cow

Entrez Gene: 100050745 Horse

Entrez Gene: 100388743 Marmoset (common)

Entrez Gene: 321019 Mouse

Entrez Gene: 679975 Rat

Omim: 605741 Human

SwissProt: Q1RMI1 Cow

SwissProt: P32249 Human

SwissProt: Q3U6B2 Mouse

SwissProt: D4A7K7 Rat

Unigene: 784 Human

Unigene: 265618 Mouse

Unigene: 179130 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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