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Rabbit Anti-ENOX1/AF647 Conjugated antibody (bs-14597R-AF647)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-14597R-AF647
英文名称 Anti-ENOX1/AF647
中文名称 AF647标记的ENOX1蛋白抗体
别    名 bA64J21.1; Candidate growth related and time keeping constitutive hydroquinone [NADH] oxidase; Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase; cCNOX; Cell proliferation inducing gene 38 protein; Cell proliferation-inducing gene 38 protein; cNOX; Constitutive Ecto NOX; Constitutive Ecto-NOX; Ecto NOX disulfide thiol exchanger 1; ENOX1; ENOX1_HUMAN; FLJ10094; OTTHUMP00000018332; PIG38; Proliferation inducing protein 38; Protein disulfide-thiol oxidoreductase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ENOX1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Function:
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.

Subcellular Location:
Cell membrane. Secreted; extracellular space. Extracellular and plasma membrane-associated.

Tissue Specificity:
Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.

Similarity:
Belongs to the ENOX family.
Contains 1 RRM (RNA recognition motif) domain.

Database links:

Entrez Gene: 10495 Human

Entrez Gene: 55068 Human

Entrez Gene: 209224 Mouse

Entrez Gene: 239188 Mouse

Entrez Gene: 306038 Rat

Omim: 610914 Human

SwissProt: Q16206 Human

SwissProt: Q8TC92 Human

SwissProt: Q8BHR2 Mouse

SwissProt: Q8R0Z2 Mouse

Unigene: 128258 Human

Unigene: 171458 Human

Unigene: 327730 Mouse

Unigene: 441158 Mouse

Unigene: 490096 Mouse

Unigene: 212211 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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