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Rabbit Anti-KCNN1/PE-Cy5.5 Conjugated antibody (bs-16910R-PE-Cy5.5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-16910R-PE-Cy5.5
英文名称 Rabbit Anti-KCNN1/PE-Cy5.5 Conjugated antibody
中文名称 PE-Cy5.5标记的电导钙激活钾通道蛋白1抗体
别    名 hSK1; KCa2.1; KCNN 1; KCNN 1; Kcnn1; KCNN1_HUMAN; Potassium intermediate/small conductance calcium activated channel subfamily N member 1; SK; SK1; SKCa 1; SKCA1; Small conductance calcium activated potassium channel protein 1; Small conductance calcium-activated potassium channel protein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  通道蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNN1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Subcellular Location:
Membrane.

Similarity:
Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.

Database links:

Entrez Gene: 3780 Human

Entrez Gene: 84036 Mouse

Entrez Gene: 54261 Rat

Omim: 602982 Human

SwissProt: Q92952 Human

SwissProt: Q9EQR3 Mouse

SwissProt: P70606 Rat

Unigene: 158173 Human

Unigene: 32074 Mouse

Unigene: 44422 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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