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Rabbit Anti-phospho-Moesin (Thr558)/Gold Conjugated antibody (bs-17703R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-17703R-Gold
英文名称 Rabbit Anti-phospho-Moesin (Thr558)/Gold Conjugated antibody
中文名称 胶体金标记的磷酸化膜突蛋白抗体
别    名 Moesin (phospho T558); p-Moesin (phospho T558); Membrane organizing extension spike protein; Membrane-organizing extension spike protein; MOES_HUMAN; Moesin; Moesin/anaplastic lymphoma kinase fusion protein; MSN; MSN/ALK fusion.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
产品类型 磷酸化抗体 
研究领域 细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Moesin around the phosphorylation site of Thr558
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane.

Subcellular Location:
Cell membrane. Cytoplasm; cytoskeleton. Apical cell membrane. Cell projection; microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.

Tissue Specificity:
In all tissues and cultured cells studied.

Post-translational modifications:
Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.

Similarity:
Contains 1 FERM domain.

Database links:

Entrez Gene: 4478 Human

Entrez Gene: 17698 Mouse

Omim: 309845 Human

SwissProt: P26038 Human

SwissProt: P26041 Mouse

Unigene: 87752 Human

Unigene: 138876 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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