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Rabbit Anti-ZFAT/ZNF406/Cy5 Conjugated antibody (bs-18521R-Cy5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-18521R-Cy5
英文名称 Anti-ZFAT/ZNF406/Cy5
中文名称 Cy5标记的锌指蛋白406抗体
别    名 AITD3; KIAA1485; MGC126815; MGC126817; ZFAT; ZFAT zinc finger 1; ZFAT_HUMAN; ZFAT1; zinc finger and AT hook domain containing; Zinc finger gene in AITD susceptibility region; zinc finger gene in autoimmune thyroid disease; Zinc finger protein 406; Zinc finger protein ZFAT; ZNF406;  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  淋巴细胞  t-淋巴细胞  b-淋巴细胞  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZFAT/ZNF
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

Function:
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated.

Subcellular Location:
Nucleus. Cytoplasm > cytosol.

Tissue Specificity:
Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes.

Similarity:
Contains 19 C2H2-type zinc fingers.

Database links:

Entrez Gene: 522282 Cow

Entrez Gene: 482051 Dog

Entrez Gene: 57623 Human

Entrez Gene: 380993 Mouse

Entrez Gene: 362925 Rat

Omim: 610931 Human

SwissProt: Q9P243 Human

SwissProt: Q7TS63 Mouse

Unigene: 446172 Human

Unigene: 309526 Mouse

Unigene: 33031 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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