| 产品编号 | bs-18712R-Gold |
| 英文名称 | Anti-MCAF2/Gold |
| 中文名称 | 胶体金标记的活化转录因子7相互作用蛋白2抗体 |
| 别 名 | 4930558K11Rik; Activating transcription factor 7-interacting protein 2; ATF7 interacting protein 2; Atf7ip2; BC018510; FLJ12668; Get 1; MBD1-containing chromatin-associated factor 2; MCAF2; MCAF2_HUMAN; MGC6783; OTTHUMP00000160168; Protein similar to MCAF2; PSM2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul（10nm 15nm 35nm） |
| 研究领域 | 神经生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, (predicted: Dog, Pig, Cow, Horse, Sheep, ) |
| 产品应用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 76kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MCAF2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存条件 | Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
background: MCAF2 is a 682 amino acid nuclear protein that exists as two alternatively spliced isoforms. MCAF2 can act as either an activator or repressor, thereby modulating chromatin formation and/or transcription regulation by linking transcription factors to transcription apparatuses. A member of the MCAF family, MCAF2 contains one fibronectin type-III domain and is thought to form a complex with ESET and MBD1. The gene encoding MCAF2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity Subunit: Interacts with MBD1, SETDB1 and SP1. Probably forms a complex with SETDB1 and MBD1. Subcellular Location: Nucleus. Similarity: Belongs to the MCAF family. Contains 1 fibronectin type-III domain. Database links: Entrez Gene: 80063 Human Entrez Gene: 75329 Mouse Omim: 613645 Human SwissProt: Q5U623 Human SwissProt: Q3UL97 Mouse Unigene: 513343 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
