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Rabbit Anti-MCF2L2/Gold Conjugated antibody (bs-18723R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-18723R-Gold
英文名称 Anti-MCF2L2/Gold
中文名称 胶体金标记的MCF2变换序列样蛋白2抗体
别    名 ARHGEF22; Dbs related Rho family guanine nucleotide exchange factor; Dbs-related Rho family guanine nucleotide exchange factor; DKFZp686K0690; DRG; FLJ42509; KIAA0861; MCF.2 cell line derived transforming sequence like 2; MCF2 transforming sequence like protein 2; MCF2-transforming sequence-like protein 2; MCF2L2; MF2L2_HUMAN; Probable guanine nucleotide exchange factor MCF2L2; Rho family guanine nucleotide exchange factor.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 肿瘤  细胞生物  神经生物学  信号转导  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 127kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MCF2L2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
MCF2L2 is a 1,114 amino acid protein that contains one spectrin repeat, one PH domain, one DH domain and one CRAL-TRIO domain. Expressed at high levels in brain and also present in testis and pancreas, MCF2L2 is thought to function as a GEF, catalyzing the activation of target GTPases. Variations in the gene encoding MCF2L2 may be associated with an increased susceptibility to type 2 diabetes. Multiple isoforms of MCF2L2 exist due to alternative splicing events.

Function:
Probably functions as a guanine nucleotide exchange factor.

Tissue Specificity:
Significantly expressed in brain and modestly in pancreas, brain and testis.

DISEASE:
Genetic variation in MCF2L2 may be associated with susceptibility to noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2.

Similarity:
Belongs to the MCF2 family.
Contains 1 CRAL-TRIO domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 spectrin repeat.

Database links:

Entrez Gene: 23101 Human

SwissProt: Q86YR7 Human

Unigene: 208267 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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