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Rabbit Anti-SMCP/AF488 Conjugated antibody (bs-20082R-AF488)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-20082R-AF488
英文名称 Anti-SMCP/AF488
中文名称 AF488标记的精子线粒体相关富含半胱氨酸蛋白抗体
别    名 HSMCSGEN1; MCS; MCSP; MCSP_HUMAN; Mitochondrial capsule selenoprotein; SMCP; Sperm mitochondria associated cysteine rich protein; Sperm mitochondrial-associated cysteine-rich protein.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  干细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SMCP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SMCP is a 116 amino acid cytoplasmic protein that is found in the outer capsule that is associated with sperm mitochondria. Expressed specifically in spermatids of seminiferous tubules, SMCP is thought to be involved in the organization and stabilization of the helical sheath structure and may play a role in overall sperm motility. SMCP has a short N-terminal segment, a C-terminal lysine and several internal cysteines. Defects in the gene encoding SMCP may be a cause of male infertility due to both reduced sperm motility and an inability to pierce the zona pellucida of the female egg.

Function:
Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida.

Subcellular Location:
Cytoplasm. Mitochondrion membrane. Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis.

Tissue Specificity:
Testis. Is selectively expressed in the spermatids of seminiferous tubules.

Database links:

Entrez Gene: 4184 Human

Omim: 601148 Human

SwissProt: P49901 Human

Unigene: 111850 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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