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Rabbit Anti-PLA2G1B/AF594 Conjugated antibody (bs-12697R-AF594)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-12697R-AF594
英文名称 Anti-PLA2G1B/AF594
中文名称 AF594标记的分泌型磷脂酶A2抗体
别    名 Group IB phospholipase A2; Group IB secretory phospholipase A2; MGC119834; MGC119835; PA21B_HUMAN; Phosphatidylcholine 2 acylhydrolase; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; Phospholipase A2 group IB (pancreas); Phospholipase A2 group IB; PLA 2; PLA2; PLA2A; PLA2G1B; PPLA 2; PPLA2; sPLA2IB.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PLA2G1B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Subunit:
Monomer or homodimer (By similarity). The inactive pro-form is a homotrimer.

Subcellular Location:
Secreted.

Post-translational modifications:
Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.

Similarity:
Belongs to the phospholipase A2 family.

Database links:

Entrez Gene: 5319 Human

Entrez Gene: 18778 Mouse

Omim: 172410 Human

SwissProt: P04054 Human

SwissProt: Q9Z0Y2 Mouse

Unigene: 992 Human

Unigene: 20190 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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