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Cat. Number:

bs-17111R-AF350

Quantity size:

100ul

Concentration:

1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

LAX1 is a 398 amino acid single-pass type III membrane protein that negatively regulates lymphocyte signaling. LAX1 is expressed in lymphoid tissues including thymus, spleen and peripheral blood leukocytes, along with several B-cell, T-cell, natural killer and monocyte cell lines. When stimulated by B or T cells, LAX1 becomes dramatically upregulated and also interacts with GRB2, Gads and PI 3-kinase p85 upon phosphorylation. LAX1 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 1. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.

Also known as:

FLJ20340; LAT like membrane associated protein; LAX; LAX1_HUMAN; Linker for activation of X cells; Lymphocyte transmembrane adaptor 1; Membrane associated adapter protein LAX; OTTHUMP00000034094.

Specificity:

Storage:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Application:

Excitation spectrum: 346nm
Emission spectrum: 422nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.