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Cat. Number:

bs-17714R-Gold

Quantity size:

100ul   15nm

Concentration:

0.4mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and, thus, to a cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. MCT14 (monocarboxylate transporter 14), also known as SLC16A14 (solute carrier family 16, member 14), is a 510 amino acid multi-pass membrane protein that belongs to the MCT family and functions as a proton-linked monocarboxylate transporter, effectively catalyzing the rapid transport of monocarboxylates across the membrane. Multiple isoforms of MCT14 exist due to alternative splicing events.

Also known as:

Monocarboxylate transporter 14; FLJ30794; MCT 14; MCT14; Monocarboxylate transporter 14; MOT14_HUMAN; OTTHUMP00000204389; OTTHUMP00000204390; Slc16a14; Solute carrier family 16 (monocarboxylic acid transporters), member 14; Solute carrier family 16 member 14; Solute carrier family 16, member 14 (monocarboxylic acid transporter 14).

Specificity:

Storage:

0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.

Application:

Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.