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Rabbit  Anti-MIER3/PE-Cy5
Cat. Number:
bs-18939R-PE-Cy5
Quantity size:
100ul
Concentration:
1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The mesoderm induction early response (MIER) protein family (also known as the fibroblast growth factor (FGF)-regulated immediate-early protein family) comprises a group of proteins that are activated by FGF (fibroblast growth factor). This suggests that MEIR proteins may play a significant role in FGF-regulated cellular activities and in the progression of certain cancers. MIER proteins contain one SANT domain, which is involved in transcriptional activation and repression, and one ELM2 domain, which was first characterized in egl-27, a gene that is critically involved in embryonic patterning of C. elegans. MIER1, formerly known as early response 1 (ER1), was first cloned and characterized in Xenopus. Expression of MIER1 is negligible in most normal tissues, but has been found to be upregulated in breast carcinoma cell lines and tumors. MIER1 functions as a transcriptional repressor of a number of genes including Sp1 target genes, most likely through interaction with HDAC1.
Also known as:
DKFZp686L09111; DKFZp781G1119; DKFZP781I1119; FLJ35954; Mesoderm induction early response 1 family member 3; Mesoderm induction early response protein 3; Mi-er3; MIER 3; MIER3; MIER3_HUMAN.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: (predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human MIER3.
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Predicted Molecular Weight: 61kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:

Excitation spectrum: 488nm,561nm,649nm
Emission spectrum: 667nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.