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Rabbit
Anti-phospho-RUNX1 (Ser276)/AF555
Cat. Number:
bs-18969R-AF555
Quantity size:
100ul
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Also known as:
RUNX1 / AML1 (phospho S276); p-RUNX1 / AML1 (phospho S276); Runx1 (phospho S276);
Acute myeloid leukemia 1 protein;
Acute myloid leukemiaprotein 1;
AML1;
AML1 CORE-BINDING FACTOR, RUNT DOMAIN, ALPHA , SUBUNIT 2;
AML1-EVI-1;
AMLCR1;
CBF-alpha-2;
CBF-alpha2;
CBFA2;
Core-binding factor subunit alpha-2;
EVI-1;
Oncogene AML-1;
PEA2-alpha B;
PEBP2-alpha B;
PEBP2A2;
PEBP2aB;
Polyomavirus enhancer-binding protein 2 alpha B subunit;
Runt-related transcription factor 1;
Runx1;
RUNX1_HUMAN;
SL3-3 enhancer factor 1 alpha B subunit;
SL3/AKV core-binding factor alpha B subunit.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthesised phosphopeptide derived from human RUNX1 around the phosphorylation site of Ser276.
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Predicted Molecular Weight: 49kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Excitation spectrum: 556nm
Emission spectrum: 572nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.