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Rabbit  Anti-Nephronectin/Cy3
Cat. Number:
bs-19202R-Cy3
Quantity size:
100ul
Concentration:
1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Nephronectin is a 565 amino acid member of the nephronectin family that contains five EGF-like domains and an Arg-Gly-Asp (RGD) cell binding motif, as well as a meprin, A5 protein and receptor protein-tyrosine phosphatase µ (MAM) domain. Expressed in kidney, thyroid and parathyroid glands, developing bone, tooth germ, skeletal and smooth muscle, brain and skin, POEM is involved in the development and function of bone, muscle and kidney tissue. The most established function of POEM is as a ligand to the receptor Integrin å8/∫1. Highly expressed in the nephritic cord, Integrin å8/∫1 plays a critical role in kidney morphogenesis and development. The POEM-Integrin å8∫1 complex regulates the expression of GDNF, another protein that affects kidney development, specifically by regulating the growth of the uretic bud. There are two named isoforms of POEM, both of which form homodimers or homotrimers.
Also known as:
EGFL6L; Nephronectin; NPNT; NPNT_HUMAN; POEM; Preosteoblast EGF like repeat protein with MAM domain; Preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6 like; Protein EGFL6-like.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: (predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human Nephronectin.
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Predicted Molecular Weight: 59kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:

Excitation spectrum: 514nm,552nm
Emission spectrum: 570nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.