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Rabbit
Anti-NLRP8/PE-Cy5.5
Cat. Number:
bs-19287R-PE-Cy5.5
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Also known as:
CLR19.2;
NACHT domain-, leucine-rich repeat-, and PYD-containing protein 8;
NACHT, leucine rich repeat and PYD containing 8;
NACHT, LRR and PYD containing protein 8;
NACHT, LRR and PYD domains-containing protein 8;
NALP8;
NALP8_HUMAN;
NLR family, pyrin domain containing 8;
NLRP8;
NOD16;
Nucleotide-binding oligomerization domain protein 16;
Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8;
PAN4;
PYRIN and NACHT-containing protein 4;
PYRIN domain- and NACHT domain-containing protein 4.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human NLRP8.
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Predicted Molecular Weight: 119kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Excitation spectrum: 496,564nm,675nm
Emission spectrum: 578nm,695nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.