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Rabbit
Anti-FBXO18 /Biotin
Cat. Number:
bs-10496R-Bio
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
FBXO18 belongs to the F-box protein family, whose members share the F-box, an approximately 40 amino acid motif. It has both DNA-dependent ATPase and DNA unwinding activities.
FBXO18 is a 1,043 amino acid protein encoded by the human gene FBXO18. FBXO18 belongs to the helicase family (UvrD subfamily) and contains one F-box domain. This nuclear protein is a DNA-dependent ATPase that unwinds double-stranded DNA in a 3' to 5' direction. FBXO18 also recognizes and binds to a variety of phosphorylated proteins and promotes their ubiquitination and degradation. It also interacts with Skp1 in the SCF E3 ubiquitin ligase complex consisting of Skp1, CUL-1, Rbx1 and FBXO18.
Also known as:
Fbx18; FLJ14590; MGC131916; MGC141935; MGC141937; F box DNA helicase 1; F box only protein 18; F box protein, helicase, 18; F-box only protein 18, F-box DNA helicase 1; FBH1; FBX18_HUMAN.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human FBXO18 .
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Predicted Molecular Weight: 118kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.