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Rabbit  Anti-CAB39L/HRP
Cat. Number:
bs-6802R-HRP
Quantity size:
100ul
Concentration:
1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Peutz-Jegers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. Mutations in the gene encoding the serine/threonine kinase LKB1 (also designated STK11) are the cause of PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-α (STRAD α) pseudo kinase and the calcium binding protein 39 (MO25, also known as CAB39). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK). CAB39L (calcium binding protein 39-like), also known as MO25L (MO25-like) or MO2L, is a 337 amino acid protein that is similar to MO25 and is found in the serum of nearly half of all patients diagnosed with acute monocytic leukemia. This suggests a role for CAB39L in carcinogenesis.
Also known as:
Antigen MLAA-34; CAB39-LIKE PROTEIN; Cab39l; Calcium-binding protein 39-like; CB39L_HUMAN; MO25-BETA; Mo25-like protein; MO2L; sarcoma antigen NY-SAR-79; U937-associated antigen.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: (predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human CAB39L.
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Predicted Molecular Weight: 39kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:

Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.