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Recombinant human GABRA1 protein, N-His
Catalog Number:
bs-42256P
General Information
Species:
Human
Host:
E.coli
AA Seq:
28-251/456
Predicted MW:
28.1
Tags:
N-His
QC Testing
Endotoxin:
Not analyzed
Purity:
>90% as determined by SDS-PAGE
Purification:
AC
Concentration:
>1mg/ml
Usage Guide
Storage:
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
Background:
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R?, GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.
Figures
VALIDATION IMAGES
 
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.