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Recombinant human ROBO4 protein, C-His (HEK293)
Catalog Number:
bs-43625P
General Information
Species:
Human
Host:
HEK293 cell
AA Seq:
28-467/1007
Predicted MW:
48.6
Tags:
C-His
QC Testing
Endotoxin:
Not analyzed
Purity:
>90% as determined by SDS-PAGE
Purification:
AC
Concentration:
>0.5mg/ml
Usage Guide
Storage:
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
Background:
Robo4 is a vascular specific receptor that is a repulsive cue to migrating endothelial cells during vascular development. Guidance and patterning of axons are orchestrated by cell surface receptors and ligands that provide directional cues. Interactions between the Robo receptor and Slit ligand families of proteins initiate signaling cascades that repel axonal outgrowth. In contrast to known neuronal Robo family members, the arrangement of the extracellular domains of Robo4 diverges significantly from that of all other Robo family members. Robo4 is specifically expressed in the vascular endothelium during murine embryonic development; the only Robo family member expressed in primary endothelial cells. Robo4 also has a role in regulating the migration of endothelial cells during tumor angiogenesis.
Figures
VALIDATION IMAGES
 
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.