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Rabbit
Anti-PAG1/HRP
Cat. Number:
bs-13695R-HRP
Quantity size:
100ul
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk. Csk binding protein (Cbp), also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk. Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src. In the plasma membrane, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signaling. Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs.
Also known as:
CBP;
Csk Binding Protein;
Csk-binding protein;
FLJ37858;
MGC138364;
PAG 1;
PAG;
PAG1;
PAG1_HUMAN;
Phosphoprotein associated with glycosphingolipid enriched microdomains 1;
Phosphoprotein associated with glycosphingolipid enriched microdomains;
Phosphoprotein associated with glycosphingolipid microdomains 1;
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1;
Protein Associated with Glycosphingolipid Enriched Microdomains;
Transmembrane adapter protein PAG;
Transmembrane phosphoprotein Cbp.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human PAG1.
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Predicted Molecular Weight: 47kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.