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Cat. Number:

bs-16611R-FITC

Quantity size:

100ul

Concentration:

1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Torsin3A is a 397 amino acid member of the clpA/clpB family of proteins. Localized to the cytoplasm and the endoplasmic reticulum, Torsin3A is most highly expressed in stomach, lymph nodes and salivary glands. Torsin3A contains a hydrophobic N-terminal sequence, an ATP binding domain and 8 putative phosphorylation sites. Highly homologous with TorsinA and TorsinB, Torsin3A is thought to be related to the AAA chaperone-like family of ATPases. Members of this family play a role in the assembly, disassembly and operation of a variety of protein complexes, confer increased tolerance to high temperature and promote specific proteolysis. Torsin3A is also referred to as an interferon responsive gene, as interaction with type 1 interferons (IFN-alpha and IFN-beta) cause a 5 to 40 fold increase in Torsin3A mRNA levels. Three isoforms of Torsin3A exist as a result of alternative splicing events, and isoform 2 is expressed exclusively in the placenta

Also known as:

ADIR; ADIR2; ATP dependant interferon response protein 1; ATP dependant interferon responsive; ATP dependent interferon responsive protein; ATP-dependent interferon-responsive protein; FLJ22345; MGC111104; Tor3a; TOR3A_HUMAN; torsin 3A; Torsin family 3 member A; torsin family 3, member A; Torsin-3A torsin family 3, member A; Torsin3A;

Specificity:

Storage:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Application:

Excitation spectrum: 495nm
Emission spectrum: 519nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.