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Rabbit
Anti-KMT5A/FITC
Cat. Number:
bs-16798R-FITC
Quantity size:
100ul
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
Also known as:
H4 K20 HMTase;
H4 K20 specific histone methyltransferase;
H4-K20-HMTase SETD8;
Histone H4 K20 methyltransferase;
Histone lysine N methyltransferase H4 lysine 20 specific;
Histone-lysine N-methyltransferase SETD8;
Lysine N-methyltransferase 5A;
N-lysine methyltransferase SETD8;
Pr SET 7;
Pr SET7;
PR-Set7;
PR/SET domain containing protein 07;
PR/SET domain containing protein 8;
PR/SET domain-containing protein 07;
PR/SET07;
PrSET7;
SET 07;
SET 8; SETD8_HUMAN;
SET domain containing (lysine methyltransferase) 8;
SET domain containing 8;
SET domain containing lysine methyltransferase 8;
SET domain containing protein 8;
SET domain-containing protein 8;
SET07;
SET8;
SETD 8.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human KMT5A.
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Predicted Molecular Weight: 43kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Excitation spectrum: 495nm
Emission spectrum: 519nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.