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Rabbit
Anti-phospho-JNK1 (Thr183)/Gold
Cat. Number:
bs-17591R-Gold
Quantity size:
100ul
35nm
Concentration:
0.4mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
Also known as:
JNK1 (phospho T183); p-JNK1 (phospho T183);
AI849689;
c Jun N terminal kinase 1;
C-JUN kinase 1;
c-Jun N-terminal kinase 1;
EC 2.7.11.24;
JNK 1;
JNK;
JNK-46;
JNK1A2;
JNK21B1/2;
MAP kinase 8;
MAPK 8;
mapk8;
Mitogen activated protein kinase 8;
Mitogen-activated protein kinase 8;
MK08_HUMAN;
p54 gamma;
Prkm8;
Protein kinase JNK1;
Protein kinase, mitogen-activated, 8;
SAPK 1;
SAPK gamma;
SAPK1;
Stress-activated protein kinase 1;
Stress-activated protein kinase JNK1.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated synthesised phosphopeptide derived from human JNK1 around the phosphorylation site of Thr183.
●
Predicted Molecular Weight: 50kDa.
Storage:
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.