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Cat. Number:

bs-3012R-AF594

Quantity size:

100ul

Concentration:

1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the Bcl2 family of proteins containing a Bcl2 homology domain 3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the Bcl2 family like Bcl2, BclxL and Bclw. Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis.

Also known as:

BCL2 like 11; Apoptosis facilitator;BAM; Bcl 2 interacting mediator of cell death; Bcl 2 interacting protein Bim; Bcl 2 like protein 11; Bcl 2 related ovarian death agonis; Bcl 2 related ovarian death agonist; BCL2 interacting mediator of cell death; BCL2 interacting protein Bim; BCL2 like 11 (apoptosis facilitator); BCL2 like 11; BCL2 like 11 apoptosis facilitator; BCL2 like protein 11; BCL2 related ovarian death agonist; BCL2L11; BIM alpha3; BIM alpha4; BIM alpha5; BIM alpha6; BIM; BIM beta6; BIM beta7; BimEL; BimL; BOD; B2L11_HUMAN.

Specificity:

Storage:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Application:

Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.