www.bioss.com.cn
400-901-9800
sales@bioss.com.cn
techsupport@bioss.com.cn
400-901-9800
sales@bioss.com.cn
techsupport@bioss.com.cn
Rabbit
Anti-CA153/Cy5
Cat. Number:
bs-4763R-Cy5
Quantity size:
100ul
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
Also known as:
Breast carcinoma associated antigen DF3;
Breast carcinoma associated antigen DF3;
Breast carcinoma-associated antigen DF3;
CA 15 3;
CA 15-3;
CA15 3;
CA15 3 antigen;
CA15.3;
Cancer antigen 15-3;
Carcinoma associated mucin;
Carcinoma associated mucin;
Carcinoma-associated mucin;
CD 227;
CD227;
CD227;
CD227 antigen;
DF3 antigen;
DF3 antigen;
EMA;
EMA;
Episialin;
Episialin;
Epithelial membrane antigen;
Epithelial membrane antigen;
Epithelial mucin tandem repeat sequence;
H23 antigen;
H23 antigen;
H23AG;
H23AG;
HGNC:7508;
KL 6;
KL-6;
KL6;
Krebs von den Lungen-6;
MAM 6;
MAM6;
MUC 1;
MUC 1;
MUC-1;
MUC-1/SEC;
MUC-1/X;
MUC1;
MUC1-alpha;
MUC1-beta;
MUC1-CT;
MUC1-NT;
MUC1/ZD;
MUC1_HUMAN;
Mucin 1;
Mucin 1 precursor;
Mucin 1 transmembrane;
Mucin-1 subunit beta;
Mucin1;
Mucin1;
Peanut reactive urinary mucin;
Peanut reactive urinary mucin;
Peanut-reactive urinary mucin;
PEM;
PEMT;
PEMT;
Polymorphic epithelial mucin;
Polymorphic epithelial mucin;
PUM;
PUM;
Tumor associated epithelial membrane antigen;
Tumor associated epithelial membrane antigen;
Tumor associated epithelial mucin;
Tumor associated mucin;
Tumor associated mucin;
Tumor-associated epithelial membrane antigen;
Tumor-associated mucin.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated synthetic peptide derived from human CA153/EMA/MUC1.
●
Predicted Molecular Weight: 138kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Excitation spectrum: 649nm
Emission spectrum: 670nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.