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Rabbit
Anti-SMAD8/Gold
Cat. Number:
bs-8844R-Gold
Quantity size:
100ul
35nm
Concentration:
0.4mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Also known as:
AI528653 ;
BSP 1 ;
BSP1 ;
DKFZp781C1895 ;
DKFZp781O1323 ;
Dwarfin A ;
Dwf A ;
DwfA ;
Dwfc ;
hSMAD1 ;
hSmad5 ;
JV 41 ;
JV4 1 ;
JV41 ;
JV5 1 ;
MAD (mothers against decapentaplegic, Drosophila) homolog 1 ;
MAD (mothers against decapentaplegic, Drosophila) homolog 9 ;
MAD homolog 1 ;
MAD homolog 9 ;
MAD homolog1 (mothers against decapentaplegic, Drosophila) ;
Mad related protein 1 ;
MAD, mothers against decapentaplegic homolog 9 ;
MADH 1 ;
Madh1 ;
MADH5 ;
MADH6 ;
MADH9 ;
Madr 1 ;
MADR1 ;
Mlp1 ;
Mothers against decapentaplegic, drosophila, homolog of, 9 ;
Mothers against DPP homolog 1 ;
Mothers against DPP homolog 9 ;
MusMLP ;
OTTHUMP00000178565 ;
OTTMUSP00000022970 ;
OTTMUSP00000022971 ;
OTTMUSP00000022972 ;
OTTMUSP0000002324 ;
OTTMUSP00000023428 ;
Sma and Mad related protein 1 ;
Sma- and Mad-related protein 1 ;
SMAD ;
SMAD family member 5 ;
SMAD mothers against DPP homolog 1 Drosophila ;
SMAD8 ;
SMAD8A ;
SMAD8B ;
Spinal muscular atrophy distal with upper limb predominance ;
TGF beta signaling protein 1 ;
Transforming growth factor beta signaling protein 1 ;
Transforming growth factor-beta signaling protein 1.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated synthetic peptide derived from human SMAD8.
●
Predicted Molecular Weight: 53kDa.
Storage:
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.