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Catalog Number:

bs-10841P

Species:

Human

Host:

E.coli

AA Seq:

1-393/393

Predicted MW:

43

Detected MW:

57 kDa

Tags:

C-His

Activity:

Not tested

Endotoxin:

Not analyzed

Purity:

>95% as determined by SDS-PAGE

Purification:

AC

Storage:

Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

Background:

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].