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Cat. Number:

bs-23726R-FITC

Quantity size:

100ul

Concentration:

1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

SBNO2 is a 1,366 amino acid protein that belongs to the SBNO family. Detected in macrophages, SBNO2 seems to have transcriptional repression activity. SBNO2 and ETV3 are components of the pathways that contribute to the downstream anti-inflammatory effects of IL-10. The expression of SBNO2 is regulated by IL-10 in a STAT3-dependent way. Existing as two alternatively spliced isoforms, the SBNO2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish and C.elegans, and maps to human chromosome 19p13.3. GPx-4 and LKB1 are neighbors of SBNO2 on chromosome 19. Chromosome 19 consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19.

Also known as:

FLJ00173; KIAA0963; Protein strawberry notch homolog 2; SBNO2; Sno; Stno.

Specificity:

Storage:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Application:

Excitation spectrum: 495nm
Emission spectrum: 519nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.