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Recombinant human Haptoglobin, His (HEK293)
Catalog Number:
bs-43006P
General Information
Species:
Human
Host:
HEK293 cell
AA Seq:
19-406/406
Predicted MW:
47
Detected MW:
60 kDa
Tags:
His
QC Testing
Activity:
Yes
Endotoxin:
Not analyzed
Purity:
>95% as determined by SDS-PAGE
Purification:
AC
Concentration:
>0.5 mg/ml
Usage Guide
Storage:
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Figures
VALIDATION IMAGES
 
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.