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Recombinant Chinese cobra Cytotoxin 1 protein, His
Catalog Number:
bs-49194P
General Information
Species:
Cobra
Host:
E.coli
AA Seq:
22-81/81
Predicted MW:
22.2
Detected MW:
27 kDa
Tags:
His
QC Testing
Activity:
Not tested
Endotoxin:
Not analyzed
Purity:
>95% as determined by SDS-PAGE
Purification:
AC
Concentration:
＞0.5 mg/ml
Usage Guide
Storage:
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
Background:
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation (By similarity).
It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity and inhibits protein kinases C (PubMed:8448165).
It also binds with high affinity to heparin (PubMed:17685633).
Figures
VALIDATION IMAGES
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.