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Cat. Number:

bs-8279R-FITC

Quantity size:

100ul

Concentration:

1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

NuAR is a multi-protein histone acetyltransferase complex that functions to acetylate the nucleosomal Histones H4 and H2A, thereby activating transcription of select target genes. p400, also known as EP400 (E1A binding protein p400) or mDomino, localizes to the nucleus and is a component of the NuAR complex. Expressed in brain, liver, thymus, lung, spleen, colon and kidney, p400 regulates the transcriptional activity of proteins such as MZF-1 and contributes to the ATPase and helicase activities of NuA4. p400 is a SWI2/ SNF2-related protein that can interact with the adenovirus oncoprotein E1A, thus activating the proapoptotic activity of E1A. The ability of p400 to regulate transcriptional and apoptotic activity suggests that the NuAR complex may be a crucial component of cell proliferation, transformation and, possibly, carcinogenesis. Five isoforms of p400 exist due to alternative splicing events.

Also known as:

CAG repeat protein 32; CAGH32; DKFZP434I225; Domino homolog; E1A binding protein p400; EP 400; EP400; FLJ42018; FLJ45115; hDomino; KIAA1498; KIAA1818; p400 kDa SWI2/SNF2 related protein; P400 SWI2/SNF2-related protein; TNRC12; Trinucleotide repeat containing 12; Trinucleotide repeat containing gene 12 protein; EP400_HUMAN.

Specificity:

Storage:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Application:

Excitation spectrum: 495nm
Emission spectrum: 519nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.