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Rabbit
Anti-IGF2R/M6PR/AF350
Cat. Number:
bs-6670R-AF350
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Also known as:
300 kDa mannose 6-phosphate receptor;
Cation independent mannose 6 phosphate receptor;
Cation-independent mannose-6-phosphate receptor;
CD222;
CD222 antigen;
CI Man 6 P receptor;
CI Man-6-P receptor;
CI MPR;
CI-MPR;
CIMPR;
IGF 2 receptor;
IGF 2R;
IGF II receptor;
IGF-II receptor;
IGF2 receptor;
IGF2R;
Insulin like growth factor 2 receptor;
Insulin like growth factor II receptor;
Insulin-like growth factor 2 receptor;
Insulin-like growth factor II receptor;
M6P R;
M6P/IGF2 receptor;
M6P/IGF2R;
M6PR;
MPR 300;
MPR300;
MPRI;
MPRI_HUMAN.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated synthetic peptide derived from human IGF2R.
●
Predicted Molecular Weight: 300kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Excitation spectrum: 346nm
Emission spectrum: 422nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.